Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer
نویسنده
چکیده
Krisenko, Mariya Ph.D., Purdue University, May 2015. Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer. Major professor: Robert L. Geahlen. The Syk protein-tyrosine kinase, a well-characterized modulator of immune recognition receptor signaling, also plays important, but poorly characterized, roles in tumor progression, acting as an inhibitor of cellular motility and metastasis in highly invasive cancer cells. Multiharmonic atomic force microscopy (AFM) was used to map nanomechanical properties of live MDA-MB231 breast cancer cells either lacking or expressing Syk. The expression of Syk dramatically altered the cellular topography, reduced cell height, increased elasticity, increased viscosity, and allowed visualization of a more substantial microtubule network. The microtubules of Syk-expressing cells were more stable
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